Marcin J. Suskiewicz

Marcin J. Suskiewicz

A structural biologist and biochemist at the Centre de Biophysique Moléculaire, CNRS, Orléans, France. Interested in protein modifications and interactions.

Publications

Publications are listed in a chronological order from the oldest to the most recent.

✱ - equal contribution; ✉ - corresponding author; 🅡 – review article; 🅝 – news & views article; 🅟 – pre-print

  1. Suskiewicz, M. J., Sussman, J. L.✉, Silman, I. & Shaul, Y.✉ Context-dependent resistance to proteolysis of intrinsically disordered proteins. Protein Sci. 20, 1285–1297 (2011). 🅡
  2. Suskiewicz, M. J. & Clausen, T.✉ Chemical biology interrogates protein arginine phosphorylation. Cell Chem. Biol. 23, 888–890 (2016). 🅝
  3. Trentini, D. B.✱, Suskiewicz, M. J.✱, Heuck, A., Kurzbauer, R., Deszcz, L., Mechtler, K. & Clausen, T. ✉ Arginine phosphorylation marks proteins for degradation by a Clp protease. Nature 539, 48–53 (2016).
  4. Heuck, A.✱, Schitter-Sollner, S.✱, Suskiewicz, M. J.✱, Kurzbauer, R., Kley, J., Schleiffer, A., Rombaut, P., Herzog, F. & Clausen, T. ✉ Structural basis for the disaggregase activity and regulation of Hsp104. Elife 5, e21516 (2016).
  5. Suskiewicz, M. J., Hajdusits, B., Beveridge, R., Heuck, A., Vu, L. D., Kurzbauer, R., Hauer, K., Thoeny, V., Rumpel, K., Mechtler, K., Meinhart, A., Clausen, T.✉ Structure of McsB, a protein kinase for regulated arginine phosphorylation. Nat. Chem. Biol. 15, 510–518 (2019).
  6. Suskiewicz, M. J., Zobel, F., Ogden, T. E. H., Fontana, P., Ariza, A., Yang, J.-C., Zhu, K., Bracken, L., Hawthorne, W. J., Ahel, D., Neuhaus, D. & Ahel, I.✉ HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation. Nature 579, 598–602 (2020).
  7. Bilokapic, S., Suskiewicz, M. J., Ahel, I. & Halic, M.✉ Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin. Nature 585, 609–613 (2020).
  8. Suskiewicz, M. J., Palazzo, L., Hughes, R. & Ahel, I.✉ Progress and outlook in studying the substrate specificities of PARPs and related enzymes. FEBS J. 288, 2131–2142 (2021). 🅡
  9. Asanović, I., Strandback, E., Kroupova, A., Pasajlic, D., Meinhart, A., Tsung-Pin, P., Djokovic, N., Anrather, D., Schuetz, T., Suskiewicz, M. J., Sillamaa, S., Köcher, T., Beveridge, R., Nikolic, K., Schleiffer, A., Jinek, M., Hartl, M., Clausen, T., Penninger, J., Macheroux, P., Weitzer, S., Martinez, J.✉ The oxidoreductase PYROXD1 uses NAD (P)+ as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response. Mol. Cell 81, 2520–2532 (2021).
  10. Prokhorova, E.✱, Agnew, T.✱, Wondisford, A. R., Tellier, M., Kaminski, N., Beijer, D., Holder, J., Groslambert, J., Suskiewicz, M. J., Zhu, K., Reber, J. M., Krassnig, S. C., Palazzo, L., Murphy, S., Nielsen, M. L., Mangerich, A., Ahel, D., Baets, J., O’Sullivan, R. J. & Ahel, I.✉ Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease. Mol. Cell 81, 2640-2655.e8 (2021).
  11. Prokhorova, E.✱, Zobel, F.✱, Smith, R., Zentout, S., Gibbs-Seymour, I., Schützenhofer, K., Peters, A., Groslambert, J., Zorzini, V., Agnew, T., Brognard, J., Nielsen, M. L., Ahel, D., Huet, S., Suskiewicz, M. J.✉ & Ahel, I.✉ Serine-linked PARP1 auto-modification controls PARP inhibitor response. Nat. Commun. 12, 4055 (2021).
  12. Hajdusits, B.✱, Suskiewicz, M. J.✱, Hundt, N.✱, Meinhart, A., Kurzbauer, R., Leodolter, J., Kukura, P.✉ & Clausen, T.✉ McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation. Elife 10, e63505 (2021).
  13. Palazzo, L., Suskiewicz, M. J. & Ahel, I.✉ Serine ADP-ribosylation in DNA-damage response regulation. Curr. Opin. Genet. Dev. 71, 106–113 (2021). 🅡
  14. Bergoug, M., Mosrin, C., Godin, F., Doudeau, M., Sosic, I., Suskiewicz, M., Vallée, B. & Bénédetti, H.✉ Noncanonical structural requirements of neurofibromin SUMOylation reveal a folding-deficiency of several pathogenic mutants. bioRxiv 2021–12 (2021). 🅟
  15. Zhu, K., Suskiewicz, M. J.✉, Hloušek-Kasun, A., Meudal, H., Mikoč, A., Aucagne, V.✉, Ahel, D.✉ & Ahel, I. DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates. Sci. Adv. 8, eadd4253 (2022).
  16. Hunia, J., Gawalski, K., Szredzka, A., Suskiewicz, M. J. & Nowis, D.✉ The potential of PARP inhibitors in targeted cancer therapy and immunotherapy. Front. Mol. Biosci. 9, 1073797 (2022). 🅡
  17. Fontana, P., Buch-Larsen, S. C., Suyari, O., Smith, R., Suskiewicz, M. J., Schützenhofer, K., Ariza, A.✉, Rack, J. G. M.✉, Nielsen, M. L.✉& Ahel, I.✉ Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling. Nat. Commun. 14, 3200 (2023).
  18. Goffinont, S., Coste, F., Prieu-Serandon, P., Mance, L., Gaudon, V., Garnier, N., Castaing, B. & Suskiewicz, M. J.✉ Structural insights into the regulation of the human E2∼SUMO conjugate through analysis of its stable mimetic. J. Biol. Chem. 299, (2023).
  19. Suskiewicz, M. J.✉✱, Munnur, D.✱, Strømland, Ø.✱, Yang, J.-C., Easton, L. E., Chatrin, C., Zhu, K., Baretić, D., Goffinont, S., Schuller, M., Wu, W.-F., Elkins, J. M., Ahel, D., Sanyal, S., Neuhaus, D. & Ahel, I.✉ Updated protein domain annotation of the PARP protein family sheds new light on biological function. Nucleic Acids Res. gkad514. doi:10.1093/nar/gkad514 (2023)
  20. Suskiewicz, M. J., Prokhorova, E., Rack, J.G.M., Ahel, I.✉ ADP-ribosylation from molecular mechanisms to therapeutic implications. Cell. Oct 12;186(21):4475-95. (2023) 🅡
  21. Kang, Z.✉, Suskiewicz, M.J., Chatrin, C., Strømland, Ø., Dorsey, B. W., Aucagne, V., Ahel, D.✉, Ahel, I.✉ DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on nucleic acids. Nucleic Acids Research. 24 November, gkad1119, doi:10.1093/nar/gkad1119 (2023)
  22. Suskiewicz, M.J.✉ The logic of protein post-translational modifications (PTMs): Chemistry, mechanisms and evolution of protein regulation through covalent attachments. BioEssays. 21 January, doi:10.1002/bies.202300178 (2024) 🅡

The most recent publications might be missing - please visit my Google Scholar profile.