Marcin J. Suskiewicz

Marcin J. Suskiewicz

A structural biologist and biochemist at the Centre de Biophysique Moléculaire, CNRS, Orléans, France. Interested in protein modifications and interactions.

Publications

Publications are listed in an inverse chronological order from the most recent to the oldest.

✱ – equal contribution; ✉ – corresponding author; 🅡 – review; 🅝 – news & views; 🅟 – pre-print

  1. Bergoug, M., Mosrin, C., Godin, F., Doudeau, M., Sosic, I., Suskiewicz, M. J., Vallée, B. and Bénédetti, H.✉ An Atypical Mechanism of SUMOylation of Neurofibromin SecPH Domain Provides New Insights into SUMOylation Site Selection. The Journal of Molecular Biology (accepted 08/2024).
  2. Zhu, K.✉, Chatrin, C., Suskiewicz, M. J., Aucagne, V., Ahel, D.✉, Ahel, I.✉ Ubiquitylation of nucleic acids by specific DELTEX E3 ligases. EMBO Reports (accepted 08/2024).
  3. Mance, L., Bigot, N., Sánchez, E.Z., Coste, F.✉, Martín-González, N., Zentout, S., Biliškov, M., Pukało, Z., Mishra, A., Chapuis, C., Arteni, A.A., Lateur, A., Goffinont, S., Gaudon, V., Talhaoui, I., Casuso, I., Beaufour, M., Garnier, N., Artzner, F., Cadene, M., Huet, S., Castaing, B., & Suskiewicz, M.J.✉ Dynamic BTB-domain filaments promote clustering of ZBTB proteins. Molecular Cell, 84(13), pp.2490-2510, (2024).
  4. Zhu, K.✉, Chatrin, C., Suskiewicz, M., Aucagne, V., Ahel, D.✉ and Ahel, I.✉. Ubiquitylation of nucleic acids by DELTEX ubiquitin E3 ligase DTX3L. bioRxiv, pp.2024-04, (2024). 🅟
  5. Suskiewicz, M.J.✉ The logic of protein post‐translational modifications (PTMs): Chemistry, mechanisms and evolution of protein regulation through covalent attachments. BioEssays, 46(3), p.2300178, (2024). 🅡
  6. Zhu, K.✉, Suskiewicz, M.J., Chatrin, C., Strømland, Ø., Dorsey, B.W., Aucagne, V., Ahel, D.✉, & Ahel, I.✉. DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on nucleic acids. Nucleic Acids Res. 52(2), pp.801-815, (2024).
  7. Suskiewicz, M.J., Prokhorova, E., Rack, J.G. and Ahel, I.✉. ADP-ribosylation from molecular mechanisms to therapeutic implications. Cell. 186(21), pp.4475-4495, (2023). 🅡
  8. Suskiewicz, M. J.✉✱, Munnur, D.✱, Strømland, Ø.✱, Yang, J.-C., Easton, L. E., Chatrin, C., Zhu, K., Baretić, D., Goffinont, S., Schuller, M., Wu, W.-F., Elkins, J. M., Ahel, D., Sanyal, S., Neuhaus, D. & Ahel, I.✉ Updated protein domain annotation of the PARP protein family sheds new light on biological function. Nucleic Acids Res. 51(15), pp.8217-8236, (2023).
  9. Goffinont, S., Coste, F., Prieu-Serandon, P., Mance, L., Gaudon, V., Garnier, N., Castaing, B. & Suskiewicz, M. J.✉ Structural insights into the regulation of the human E2∼SUMO conjugate through analysis of its stable mimetic. J. Biol. Chem. 299, (2023).
  10. Fontana, P., Buch-Larsen, S. C., Suyari, O., Smith, R., Suskiewicz, M. J., Schützenhofer, K., Ariza, A.✉, Rack, J. G. M.✉, Nielsen, M. L.✉& Ahel, I.✉ Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling. Nat. Commun. 14, 3200 (2023).
  11. Hunia, J., Gawalski, K., Szredzka, A., Suskiewicz, M. J. & Nowis, D.✉ The potential of PARP inhibitors in targeted cancer therapy and immunotherapy. Front. Mol. Biosci. 9, 1073797 (2022). 🅡
  12. Zhu, K., Suskiewicz, M. J.✉, Hloušek-Kasun, A., Meudal, H., Mikoč, A., Aucagne, V.✉, Ahel, D.✉ & Ahel, I. DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates. Sci. Adv. 8, eadd4253 (2022).
  13. Coste, F.✉, Goffinont, S., Cros, J., Gaudon, V., Guérin, M., Garnier, N., Confalonieri, F., Flament, D., Suskiewicz, M. J. & Castaing, B.✉ Structural and functional determinants of the archaeal 8-oxoguanine-DNA glycosylase AGOG for DNA damage recognition and processing. Nucleic Acids Research, 50(19), pp.11072-11092. (2022)
  14. Bergoug, M., Mosrin, C., Godin, F., Doudeau, M., Sosic, I., Suskiewicz, M. J., Vallée, B. & Bénédetti, H.✉ Noncanonical structural requirements of neurofibromin SUMOylation reveal a folding-deficiency of several pathogenic mutants. bioRxiv 2021–12 (2021). 🅟
  15. Palazzo, L., Suskiewicz, M. J. & Ahel, I.✉ Serine ADP-ribosylation in DNA-damage response regulation. Curr. Opin. Genet. Dev. 71, 106–113 (2021). 🅡
  16. Hajdusits, B.✱, Suskiewicz, M. J.✱, Hundt, N.✱, Meinhart, A., Kurzbauer, R., Leodolter, J., Kukura, P.✉ & Clausen, T.✉ McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation. Elife 10, e63505 (2021).
  17. Prokhorova, E.✱, Zobel, F.✱, Smith, R., Zentout, S., Gibbs-Seymour, I., Schützenhofer, K., Peters, A., Groslambert, J., Zorzini, V., Agnew, T., Brognard, J., Nielsen, M. L., Ahel, D., Huet, S., Suskiewicz, M. J.✉ & Ahel, I.✉ Serine-linked PARP1 auto-modification controls PARP inhibitor response. Nat. Commun. 12, 4055 (2021).
  18. Prokhorova, E.✱, Agnew, T.✱, Wondisford, A. R., Tellier, M., Kaminski, N., Beijer, D., Holder, J., Groslambert, J., Suskiewicz, M. J., Zhu, K., Reber, J. M., Krassnig, S. C., Palazzo, L., Murphy, S., Nielsen, M. L., Mangerich, A., Ahel, D., Baets, J., O’Sullivan, R. J. & Ahel, I.✉ Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease. Mol. Cell 81, 2640-2655.e8 (2021).
  19. Asanović, I., Strandback, E., Kroupova, A., Pasajlic, D., Meinhart, A., Tsung-Pin, P., Djokovic, N., Anrather, D., Schuetz, T., Suskiewicz, M. J., Sillamaa, S., Köcher, T., Beveridge, R., Nikolic, K., Schleiffer, A., Jinek, M., Hartl, M., Clausen, T., Penninger, J., Macheroux, P., Weitzer, S., Martinez, J.✉ The oxidoreductase PYROXD1 uses NAD (P)+ as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response. Mol. Cell 81, 2520–2532 (2021).
  20. Suskiewicz, M. J., Palazzo, L., Hughes, R. & Ahel, I.✉ Progress and outlook in studying the substrate specificities of PARPs and related enzymes. FEBS J. 288, 2131–2142 (2021). 🅡
  21. Bilokapic, S., Suskiewicz, M. J., Ahel, I. & Halic, M.✉ Bridging of DNA breaks activates PARP2–HPF1 to modify chromatin. Nature 585, 609–613 (2020).
  22. Suskiewicz, M. J., Zobel, F., Ogden, T. E. H., Fontana, P., Ariza, A., Yang, J.-C., Zhu, K., Bracken, L., Hawthorne, W. J., Ahel, D., Neuhaus, D. & Ahel, I.✉ HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation. Nature 579, 598–602 (2020).
  23. Suskiewicz, M. J., Hajdusits, B., Beveridge, R., Heuck, A., Vu, L. D., Kurzbauer, R., Hauer, K., Thoeny, V., Rumpel, K., Mechtler, K., Meinhart, A., Clausen, T.✉ Structure of McsB, a protein kinase for regulated arginine phosphorylation. Nat. Chem. Biol. 15, 510–518 (2019).
  24. Heuck, A.✱, Schitter-Sollner, S.✱, Suskiewicz, M. J.✱, Kurzbauer, R., Kley, J., Schleiffer, A., Rombaut, P., Herzog, F. & Clausen, T. ✉ Structural basis for the disaggregase activity and regulation of Hsp104. Elife 5, e21516 (2016).
  25. Trentini, D. B.✱, Suskiewicz, M. J.✱, Heuck, A., Kurzbauer, R., Deszcz, L., Mechtler, K. & Clausen, T. ✉ Arginine phosphorylation marks proteins for degradation by a Clp protease. Nature 539, 48–53 (2016).
  26. Suskiewicz, M. J. & Clausen, T.✉ Chemical biology interrogates protein arginine phosphorylation. Cell Chem. Biol. 23, 888–890 (2016). 🅝
  27. Suskiewicz, M. J., Sussman, J. L.✉, Silman, I. & Shaul, Y.✉ Context-dependent resistance to proteolysis of intrinsically disordered proteins. Protein Sci. 20, 1285–1297 (2011). 🅡

The most recent publications might be missing - please visit my Google Scholar profile.